Comprehensive in vitro digestion and cytotoxicity study of cannabidiol-loaded nanostructured lipid carriers (ICPSR doi:10.34622/datarepositorium/ZOOLIA)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Comprehensive in vitro digestion and cytotoxicity study of cannabidiol-loaded nanostructured lipid carriers

doi:10.34622/datarepositorium/ZOOLIA

Repositório de Dados da Universidade do Minho

2025-05-27

1

Vardanega, Renata; Lüdtke, Fernanda L.; Loureiro, Luis; Gonçalves, Raquel F.S.; Martins, Joana T.; Pinheiro, Ana C.; Vicente, António A., 2025, "Comprehensive in vitro digestion and cytotoxicity study of cannabidiol-loaded nanostructured lipid carriers", https://doi.org/10.34622/datarepositorium/ZOOLIA, Repositório de Dados da Universidade do Minho, V1, UNF:6:uBeq4CyOVW+A6KKB5vRQCg== [fileUNF]

Comprehensive in vitro digestion and cytotoxicity study of cannabidiol-loaded nanostructured lipid carriers

doi:10.34622/datarepositorium/ZOOLIA

Vardanega, Renata (Universidade do Minho)

Lüdtke, Fernanda L. (Universidade do Minho)

Loureiro, Luis (Universidade do Minho)

Gonçalves, Raquel F.S. (Universidade do Minho)

Martins, Joana T. (Universidade do Minho)

Pinheiro, Ana C. (Universidade do Minho)

Vicente, António A. (Universidade do Minho)

101062938

Repositório de Dados da Universidade do Minho

Vardanega, Renata

Vardanega, Renata

2025-05-15

Chemistry, cannabidiol, in vitro digestion, delivery systems, nanostructured lipid carrier, nanostructures

This dataset contains the experimental data that support the results of the manuscript "Nanostructured lipid carriers for enhanced cannabidiol bioaccessibility: in vitro digestion study and cytotoxicity assessment." This work was developed under the scope of the project CBDHIGHBIO - Strategies to modulate the bioavailability of cannabinoids in edible products: in vitro tests, cytotoxicity, and pre-clinical assessment to generate reliable data for regulatory agencies, funded by European Commission, Programme HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA), grant 101062938. The dataset contains protocols that describe the methodologies used to evaluate in vitro digestion and cytotoxicity assessment, experimental data, and statistical results. Detailed information about the files are available in the ReadMe file.

renata.vardanega@ceb.uminho.pt

Citation of the correspondent paper should be included, if the dataset is used.

<a rel="license" href="http://creativecommons.org/licenses/by-nc/4.0/"><img alt="Creative Commons Licence" style="border-width:0" src="https://i.creativecommons.org/l/by-nc/4.0/88x31.png" /></a><br />This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution-NonCommercial 4.0 International License</a>

Until the article containg the data from this dataset is published, users can request access to the data by contacting renata.vardanega@ceb.uminho.pt

• Number of cases: 33

• No. of variables per record: 12

• Type of File: text/tab-separated-values

UNF:6:gRzOi9lroJn35AdqOrxfxQ==

• Number of cases: 3603

• No. of variables per record: 31

• Type of File: text/tab-separated-values

UNF:6:pf0KxHQasXqSm5o8/PyV2A==

• Number of cases: 60

• No. of variables per record: 12

• Type of File: text/tab-separated-values

UNF:6:WPB4WcHyr1WX8nmU+hlKdw==

• NLC - NLC
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• E - E
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• I - I
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• NLC-CBDiso1 - NLC-CBDiso1
• B - B
• C - C
• D - D
• E - E
• F - F
• G - G
• H - H
• I - I
• J - J
• K - K
• NLC-CBDiso2 - NLC-CBDiso2
• M - M
• N - N
• O - O
• P - P
• Q - Q
• R - R
• S - S
• T - T
• U - U
• NLC-CBDiso3 - NLC-CBDiso3
• W - W
• X - X
• Y - Y
• Z - Z
• AA - AA
• AB - AB
• AC - AC
• AD - AD
• AE - AE
• ConcentrationofCBDcalculatedfromthecalibrationcurvey=43625x+28827 - ConcentrationofCBDcalculatedfromthecalibrationcurvey=43625x+28827
• B - B
• C - C
• D - D
• E - E
• F - F
• G - G
• H - H
• I - I
• J - J
• K - K
• L - L

f5466 Location:

Variable Format: character

Notes: UNF:6:5J/1jX64YS8HGV6UV+Hhdg==

f5466 Location:

Summary Statistics: Mean 525.11; StDev 447.88158098565174; Max. 1302.0; Min. 159.2; Valid 30.0;

Variable Format: numeric

Notes: UNF:6:82/r2lYw+TULK+KJpOgAsg==

f5466 Location:

Summary Statistics: StDev 0.14080750698378444; Mean 0.41606666666666664; Max. 0.643; Min. 0.24; Valid 30.0

Variable Format: numeric

Notes: UNF:6:pHMZPpfynNPrBbgsF6Chqw==

f5466 Location:

Summary Statistics: StDev 20.057957244369767; Valid 30.0; Min. -53.1; Max. 1.67; Mean -22.08544

Variable Format: numeric

Notes: UNF:6:2wr8Ls+K7lkI11vwApiXEQ==

f5466 Location:

Variable Format: character

Notes: UNF:6:TYDDEhOC07XbpsSqmjDWig==

f5466 Location:

Summary Statistics: Max. 2237.7; StDev 525.3005842197485; Mean 587.2366666666667; Valid 30.0; Min. 178.7;

Variable Format: numeric

Notes: UNF:6:p4DMZl+Gr9GWvdHKIZYQlA==

f5466 Location:

Summary Statistics: StDev 0.18975423003477934; Valid 30.0; Mean 0.4787666666666667; Max. 0.881; Min. 0.228

Variable Format: numeric

Notes: UNF:6:dkJYQ8zzUKKatphHgpsV/Q==

f5466 Location:

Summary Statistics: Mean -19.626323333333335; StDev 20.02773693961802; Min. -46.3; Valid 30.0; Max. 1.16;

Variable Format: numeric

Notes: UNF:6:G3ke4GGSmSQ1u4RUNrAQXA==

f5466 Location:

Variable Format: character

Notes: UNF:6:HuZtRrtI+aiVHcvRBPs4Og==

f5466 Location:

Summary Statistics: Mean 293.4533333333333; Min. 221.5; Max. 428.6; StDev 63.80559230346038; Valid 30.0

Variable Format: numeric

Notes: UNF:6:wLbtAm6ML7BtF1Smx6R/aA==

f5466 Location:

Summary Statistics: Mean 0.3859666666666667; StDev 0.11792296823257806; Min. 0.234; Valid 30.0; Max. 0.657;

Variable Format: numeric

Notes: UNF:6:eA3eNxK212PwLJKz3Rv9BA==

f5466 Location:

Summary Statistics: Max. 3.05; Mean -26.635133333333332; Valid 30.0; StDev 19.448313214213744; Min. -50.1;

Variable Format: numeric

Notes: UNF:6:+FSjXFA1BNASGF91uMcoSA==

f5467 Location:

Variable Format: character

Notes: UNF:6:k4N0qLX+vQroCJljybhh5g==

f5467 Location:

Variable Format: character

Notes: UNF:6:5PkY1lyhYS/iTkkzDotW1Q==

f5467 Location:

Variable Format: character

Notes: UNF:6:54XjFxgezSlG7nuzxjXLHA==

f5467 Location:

Variable Format: character

Notes: UNF:6:P1MRw3v+TtU3ryUx/flGeQ==

f5467 Location:

Summary Statistics: Valid 0.0; StDev NaN; Mean NaN; Max. NaN; Min. NaN;

Variable Format: numeric

Notes: UNF:6:u06dOxD8Ax2pNRwY7cHsCw==

f5467 Location:

Variable Format: character

Notes: UNF:6:04B3V0+7wa3dpPsrhIQ0dw==

f5467 Location:

Variable Format: character

Notes: UNF:6:WM53DUXJzGhvNenBGJ7P3g==

f5467 Location:

Variable Format: character

Notes: UNF:6:vtsoNZk4xVRwqjeMVe8v1Q==

f5467 Location:

Variable Format: character

Notes: UNF:6:s1NMXxWRwbv1ayzqEdUlMQ==

f5467 Location:

Summary Statistics: Valid 814.0; Mean 19.574437346437342; Min. 0.644; Max. 26.096; StDev 7.8930934179934775

Variable Format: numeric

Notes: UNF:6:eJn2EMfj9xvdMuX1v+NFog==

f5467 Location:

Summary Statistics: Valid 0.0; StDev NaN; Max. NaN; Min. NaN; Mean NaN

Variable Format: numeric

Notes: UNF:6:u06dOxD8Ax2pNRwY7cHsCw==

f5467 Location:

Variable Format: character

Notes: UNF:6:BWF0CNSETeKPa8Du5KEKiw==

f5467 Location:

Variable Format: character

Notes: UNF:6:HLmcOtjaFGLHw11G3ZEhxQ==

f5467 Location:

Variable Format: character

Notes: UNF:6:yyZGuqJkiE7KuJVPjDuDTw==

f5467 Location:

Summary Statistics: Valid 0.0; StDev NaN; Max. NaN; Min. NaN; Mean NaN

Variable Format: numeric

Notes: UNF:6:u06dOxD8Ax2pNRwY7cHsCw==

f5467 Location:

Variable Format: character

Notes: UNF:6:r5oPF4zd4U7SqzomY7javw==

f5467 Location:

Variable Format: character

Notes: UNF:6:fsv+IEWR2RimHP5QyzA7Ug==

f5467 Location:

Variable Format: character

Notes: UNF:6:BTZwo4yoqpgyQEsc1QaGHg==

f5467 Location:

Variable Format: character

Notes: UNF:6:gJ35z2JqCuDg19XzKWVCIA==

f5467 Location:

Variable Format: character

Notes: UNF:6:gCHKgPq7ac+CsrscIlWDiA==

f5467 Location:

Summary Statistics: StDev NaN; Valid 0.0; Max. NaN; Min. NaN; Mean NaN;

Variable Format: numeric

Notes: UNF:6:u06dOxD8Ax2pNRwY7cHsCw==

f5467 Location:

Variable Format: character

Notes: UNF:6:YaD7/M0orr7qNcvYoUgBVA==

f5467 Location:

Variable Format: character

Notes: UNF:6:V1wR7mgCZy/cvWz5huRw2A==

f5467 Location:

Variable Format: character

Notes: UNF:6:g2ey6QsypUqvnd/t6UMsIA==

f5467 Location:

Variable Format: character

Notes: UNF:6:gJKUUZEZWzMYre/PvkbM+w==

f5467 Location:

Summary Statistics: StDev NaN; Max. NaN; Valid 0.0; Min. NaN; Mean NaN;

Variable Format: numeric

Notes: UNF:6:u06dOxD8Ax2pNRwY7cHsCw==

f5467 Location:

Variable Format: character

Notes: UNF:6:lbv8ieX9WthImqXMlSEmIw==

f5467 Location:

Variable Format: character

Notes: UNF:6:Aw4McGQvBTDAHgPuR2P4mA==

f5467 Location:

Variable Format: character

Notes: UNF:6:fOZBs6E0CoDYBYE+BtJxRw==

f5467 Location:

Variable Format: character

Notes: UNF:6:ARCJ1Jb3aj0EEo3Qy646pA==

f5467 Location:

Variable Format: character

Notes: UNF:6:wZs0Xp3bFb9d2xB9mUyYNw==

f5465 Location:

Variable Format: character

Notes: UNF:6:yEgonpYrz2R+SlbQB0zK6A==

f5465 Location:

Variable Format: character

Notes: UNF:6:01HGMfxIh1lIVmnZyhQDjQ==

f5465 Location:

Variable Format: character

Notes: UNF:6:zLD3SqR7ni5barA8bzEU/Q==

f5465 Location:

Variable Format: character

Notes: UNF:6:4pIhYyLzxoZG8lSNMSOAyw==

f5465 Location:

Variable Format: character

Notes: UNF:6:eeXAHC1bMTjsAYS0eN0lnQ==

f5465 Location:

Variable Format: character

Notes: UNF:6:Q5PuEfhLvOx3vNd2LQLbNw==

f5465 Location:

Variable Format: character

Notes: UNF:6:qJ/FG8MeWrSRshUaI43WlQ==

f5465 Location:

Variable Format: character

Notes: UNF:6:iyF32gt8+ZstWfOLvQbRBg==

f5465 Location:

Variable Format: character

Notes: UNF:6:hcUrUu/i+LKO7F1bCQtwDA==

f5465 Location:

Variable Format: character

Notes: UNF:6:x8sF3pBrUy3O9cLWq0mPrQ==

f5465 Location:

Variable Format: character

Notes: UNF:6:RjdsJ6v2d7vqKwWicaObyw==

f5465 Location:

Variable Format: character

Notes: UNF:6:7JSnOuI3p9OnCHYkAbChuw==

Label:

00-ReadMe.txt

text/plain

Label:

CBDHIGHBIO-101062938_Protocol_7_Cell viability.xlsx

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Label:

CBDHIGHBIO-101062938_Protocol_7_Digestion_v1.0.pdf

application/pdf