Nanostructured lipid carriers for co-delivery of cannabidiol and piperine: insights from in vitro digestion and in vivo pharmacokinetic evaluation (ICPSR doi:10.34622/datarepositorium/KV3JCU)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Nanostructured lipid carriers for co-delivery of cannabidiol and piperine: insights from in vitro digestion and in vivo pharmacokinetic evaluation

doi:10.34622/datarepositorium/KV3JCU

Repositório de Dados da Universidade do Minho

2025-12-02

1

Vardanega, Renata; Lüdtke, Fernanda L.; Loureiro, Luís; Fernández-Carrera, Andrea; Santos, Joana; Venâncio, Armando; González-Fernández, África; Pinheiro, Ana C.; Vicente, António A., 2025, "Nanostructured lipid carriers for co-delivery of cannabidiol and piperine: insights from in vitro digestion and in vivo pharmacokinetic evaluation", https://doi.org/10.34622/datarepositorium/KV3JCU, Repositório de Dados da Universidade do Minho, V1, UNF:6:L07wrMc13aGqVm8nGSCjew== [fileUNF]

Nanostructured lipid carriers for co-delivery of cannabidiol and piperine: insights from in vitro digestion and in vivo pharmacokinetic evaluation

doi:10.34622/datarepositorium/KV3JCU

Vardanega, Renata (Universidade do Minho)

Lüdtke, Fernanda L. (Universidade do Minho)

Loureiro, Luís (Universidade do Minho)

Fernández-Carrera, Andrea (Universidad de Vigo)

Santos, Joana (Universidade do Minho)

Venâncio, Armando (Universidade do Minho)

González-Fernández, África (Universidad de Vigo)

Pinheiro, Ana C. (Universidade do Minho)

Vicente, António A. (Universidade do Minho)

101062938

Repositório de Dados da Universidade do Minho

Vardanega, Renata

Vardanega, Renata

2025-05-28

Chemistry, pharmacokinetics, bioavailability, bioenhancer, lipid-based systems, cannabidiol, piperine

This dataset contains the experimental data that support the results of the manuscript: "Nanostructured lipid carriers for co-delivery of cannabidiol and piperine: insights from in vitro digestion and in vivo pharmacokinetic evaluation." This work was developed under the scope of the project CBDHIGHBIO - Strategies to modulate the bioavailability of cannabinoids in edible products: in vitro tests, cytotoxicity, and pre-clinical assessment to generate reliable data for regulatory agencies, funded by European Commission, Programme HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA), grant 101062938. The dataset contains protocols that describe the methodologies used to produce and characterise Nanostructured lipid carriers, to evaluate in vitro digestion and in vivo pharmacokinetics, experimental data, and statistical results. Detailed information about the files are available in the ReadMe file.

renata.vardanega@ceb.uminho.pt

Citation of the correspondent paper should be included, if the dataset is used.

<a rel="license" href="http://creativecommons.org/licenses/by-nc/4.0/"><img alt="Creative Commons Licence" style="border-width:0" src="https://i.creativecommons.org/l/by-nc/4.0/88x31.png" /></a><br />This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution-NonCommercial 4.0 International License</a>

Until the article containg the data from this dataset is published, users can request access to the data by contacting renata.vardanega@ceb.uminho.pt

• Number of cases: 33

• No. of variables per record: 8

• Type of File: text/tab-separated-values

UNF:6:TMzIooNnB0JoWblUhBpm4w==

• Number of cases: 7

• No. of variables per record: 16

• Type of File: text/tab-separated-values

UNF:6:A3gGewdw3tetxUdKpFGEkw==

• Number of cases: 10

• No. of variables per record: 2

• Type of File: text/tab-separated-values

UNF:6:XffvWpCcaGCI411e6il4KQ==

• Number of cases: 22

• No. of variables per record: 11

• Type of File: text/tab-separated-values

UNF:6:Sq2k2kjfLbWgW905j6zaRw==

• Number of cases: 68

• No. of variables per record: 13

• Type of File: text/tab-separated-values

UNF:6:m/IiBGE/yClrocYsrNGTUw==

• NLC - NLC
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• E - E
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• NLCs - NLCs
• 24h - 24h
• C - C
• D - D
• 7days - 7days
• F - F
• G - G
• 14days - 14days
• I - I
• J - J
• 21days - 21days
• L - L
• M - M
• 30days - 30days
• O - O
• P - P
• pHSTATASSAY - pHSTATASSAY
• B - B
• ConcentraçaodeCBDcalculadaapartirdacurvaobtidaem18.06.2024(y=80175x+14243) - ConcentraçaodeCBDcalculadaapartirdacurvaobtidaem18.06.2024(y=80175x+14243)
• B - B
• C - C
• D - D
• E - E
• F - F
• G - G
• H - H
• I - I
• J - J
• K - K
• CBD-Male - CBD-Male
• B - B
• C - C
• D - D
• E - E
• F - F
• G - G
• H - H
• I - I
• J - J
• K - K
• L - L
• M - M

f7471 Location:

Variable Format: character

Notes: UNF:6:IRP54IUblJ2IYGExR4R9xg==

f7471 Location:

Summary Statistics: Min. 222.0; Valid 27.0; Mean 2213.959259259259; StDev 1496.377034003041; Max. 4496.0

Variable Format: numeric

Notes: UNF:6:BULqfh8zhuj16tk2W22QPg==

f7471 Location:

Summary Statistics: Valid 24.0; Max. 1.0; Min. 0.349; Mean 0.6314583333333333; StDev 0.16495453370067098;

Variable Format: numeric

Notes: UNF:6:xFBi7dePhBUvkMeIWm7BIw==

f7471 Location:

Summary Statistics: Mean -6.10788888888889; Valid 27.0; Min. -47.6; Max. 2.57; StDev 14.586994880407193

Variable Format: numeric

Notes: UNF:6:U7OQqVGUnacBdB7g2WeCpA==

f7471 Location:

Variable Format: character

Notes: UNF:6:FhTVQoySFRspv3RkFZS/ag==

f7471 Location:

Summary Statistics: StDev 473.6074699434194; Min. 228.8; Max. 1752.0; Valid 30.0; Mean 642.26;

Variable Format: numeric

Notes: UNF:6:zjLilwRtG9Ga161tyV3//w==

f7471 Location:

Summary Statistics: StDev 0.24310699834368849; Min. 0.286; Valid 30.0; Max. 1.0; Mean 0.6152333333333333

Variable Format: numeric

Notes: UNF:6:KV/5i5AqOP4scHm/zp8KWA==

f7471 Location:

Summary Statistics: Valid 30.0; Mean -38.19; Max. -22.4; Min. -62.3; StDev 9.61386749835164

Variable Format: numeric

Notes: UNF:6:do3fdJSsEPmWue4fCC/H0Q==

f7467 Location:

Variable Format: character

Notes: UNF:6:8Q3Wspo/W8sTw4QtK/ClCQ==

f7467 Location:

Variable Format: character

Notes: UNF:6:P2v32Xsjh5NNd44cIYQjvg==

f7467 Location:

Variable Format: character

Notes: UNF:6:7bZ8KdsXhDW85EWEU5K1OQ==

f7467 Location:

Variable Format: character

Notes: UNF:6:AYCl6iqT2HThfvJq6axBjQ==

f7467 Location:

Variable Format: character

Notes: UNF:6:3ROTZDis2Yjr3zrg4nkPrQ==

f7467 Location:

Variable Format: character

Notes: UNF:6:jDG4bmHQxrDREQ+7ZXfkrQ==

f7467 Location:

Variable Format: character

Notes: UNF:6:D4oWdktR/y1EkE3BWaYdTQ==

f7467 Location:

Variable Format: character

Notes: UNF:6:vudTpZpFHmd3suyasrR9bA==

f7467 Location:

Variable Format: character

Notes: UNF:6:lpk6ByXVuYhaoPNLngKRlA==

f7467 Location:

Variable Format: character

Notes: UNF:6:KGMd1Up8G/p5xybusimzcA==

f7467 Location:

Variable Format: character

Notes: UNF:6:02R6qhMPEX8NS43mUxCb8w==

f7467 Location:

Variable Format: character

Notes: UNF:6:QglbUgz7esdu5X/4bJSFHw==

f7467 Location:

Variable Format: character

Notes: UNF:6:U/evcnQZzLTzN2k7V9ddgA==

f7467 Location:

Variable Format: character

Notes: UNF:6:e6MZJ2LaJJDND8GYraNOjg==

f7467 Location:

Variable Format: character

Notes: UNF:6:9dZcyIGDn26A6NXZ9VSxsQ==

f7467 Location:

Variable Format: character

Notes: UNF:6:a37sE3Hx7EutLFJd8lkdjw==

f7470 Location:

Variable Format: character

Notes: UNF:6:HN1U5fSY0AnbKEYpGvAdYA==

f7470 Location:

Variable Format: character

Notes: UNF:6:75tsfz2FUOfABYpQ/snqTQ==

f7474 Location:

Variable Format: character

Notes: UNF:6:gYiEL4O1Sl5k2LwxbU7jkA==

f7474 Location:

Variable Format: character

Notes: UNF:6:jwwFyi91b8r7stnns/4b9g==

f7474 Location:

Variable Format: character

Notes: UNF:6:Mupu7JVUrUsL6M35QODCAg==

f7474 Location:

Variable Format: character

Notes: UNF:6:E5mFoppL9dRDq84oueaTSw==

f7474 Location:

Variable Format: character

Notes: UNF:6:ZeNePd0oZjgEIOFsQFPaDA==

f7474 Location:

Variable Format: character

Notes: UNF:6:1Ypbpb/PW98NlDNYar/MHg==

f7474 Location:

Variable Format: character

Notes: UNF:6:AP1iogA3V6FL/aFT+A8NGw==

f7474 Location:

Variable Format: character

Notes: UNF:6:3aPL0WqZkgg/KAYlDzmXnQ==

f7474 Location:

Variable Format: character

Notes: UNF:6:amWpNbyJyyGmi1wVjLbRWA==

f7474 Location:

Variable Format: character

Notes: UNF:6:4PB1UjIlQL3exs2+WCh5gQ==

f7474 Location:

Variable Format: character

Notes: UNF:6:LSd+5WUSXnuG2p+XwotUMw==

f7469 Location:

Variable Format: character

Notes: UNF:6:0KiLHZQYbifZumTqwDFpvQ==

f7469 Location:

Variable Format: character

Notes: UNF:6:Yvi3/T4nI5PhrBqUnr2Klw==

f7469 Location:

Variable Format: character

Notes: UNF:6:DWuDzzU+BY/0XL/cizwuAQ==

f7469 Location:

Variable Format: character

Notes: UNF:6:xqPC0nCSL6J8YX16nqq65g==

f7469 Location:

Variable Format: character

Notes: UNF:6:hac0FqZQhWbaCap+t5C6Pg==

f7469 Location:

Variable Format: character

Notes: UNF:6:T/8cXr05eomSGOjCDizTNw==

f7469 Location:

Variable Format: character

Notes: UNF:6:tH4dAbdx0K8ZREU6pfYlFQ==

f7469 Location:

Variable Format: character

Notes: UNF:6:8ZbzjzOfNfRovgTzehImWw==

f7469 Location:

Variable Format: character

Notes: UNF:6:mU9fyGd4yJlnzrXbvdBScg==

f7469 Location:

Variable Format: character

Notes: UNF:6:kqOtIThMyj6X/GT0axEctQ==

f7469 Location:

Variable Format: character

Notes: UNF:6:qrFYd0kDgRA+HzSZPcNpSA==

f7469 Location:

Variable Format: character

Notes: UNF:6:3eJg5gole/MtmBYVc54OGQ==

f7469 Location:

Variable Format: character

Notes: UNF:6:tFR+9MQk8fK9pyFvBLp08g==

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00_ReadMe.txt

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Label:

CBDHIGHBIO-101062938_Protocol 8_v1.0.pdf

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Label:

CBDHIGHBIO-101062938_Protocol 9_v1.0.pdf

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