Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion (ICPSR doi:10.34622/datarepositorium/JCCPLY)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
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Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion

doi:10.34622/datarepositorium/JCCPLY

Repositório de Dados da Universidade do Minho

2025-03-03

1

Vardanega, Renata; Lüdtke, Fernanda L.; Loureiro, Luís; Hijo, Ariel A.C. Toledo; Martins, Joana T.; Pinheiro, Ana C.; Vicente, António A., 2025, "Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion", https://doi.org/10.34622/datarepositorium/JCCPLY, Repositório de Dados da Universidade do Minho, V1, UNF:6:SFM21C0JadmSVNnJN+Klsw== [fileUNF]

Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion

doi:10.34622/datarepositorium/JCCPLY

Vardanega, Renata (Universidade do Minho)

Lüdtke, Fernanda L. (Universidade do Minho)

Loureiro, Luís (Universidade do Minho)

Hijo, Ariel A.C. Toledo (Universidade Estadual de Campinas)

Martins, Joana T. (Universidade do Minho)

Pinheiro, Ana C. (Universidade do Minho)

Vicente, António A. (Universidade do Minho)

101062938

Repositório de Dados da Universidade do Minho

Vardanega, Renata

Vardanega, Renata

2025-02-28

Chemistry, cannabidiol, cholinium oleate, nanoemulsion, nanostructured lipid carrier, delivery systems, cannabinoids, ionic liquid

This dataset contains the experimental data that support the results published in the article: Vardanega, R. et al. (2024) Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion, Food Research International, 188, 114498, https://doi.org/10.1016/j.foodres.2024.114498. This work was developed under the scope of the project CBDHIGHBIO - Strategies to modulate the bioavailability of cannabinoids in edible products: in vitro tests, cytotoxicity, and pre-clinical assessment to generate reliable data for regulatory agencies, funded by European Commission, Programme HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA), grant 101062938. The dataset contains protocols that describe the methodologies used to produce and characterize the nanostructures, experimental data, and statistical results. Detailed information about the files are available in the ReadMe file.

Citation of the correspondent paper should be included, if the dataset is used.

<a rel="license" href="http://creativecommons.org/licenses/by-nc/4.0/"><img alt="Creative Commons Licence" style="border-width:0" src="https://i.creativecommons.org/l/by-nc/4.0/88x31.png" /></a><br />This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution-NonCommercial 4.0 International License</a>

10.1016/j.foodres.2024.114498

Vardanega, R. et al. (2024) Enhancing cannabidiol bioaccessibility using ionic liquid as emulsifier to produce nanosystems: Characterization of structures, cytotoxicity assessment, and in vitro digestion, Food Research International, 188.

• Number of cases: 31

• No. of variables per record: 11

• Type of File: text/tab-separated-values

UNF:6:0KTCurZ97GIwL9SoTzt1sg==

• Number of cases: 1022

• No. of variables per record: 14

• Type of File: text/tab-separated-values

UNF:6:LM1IEj/jcaVYxihy+qP3qA==

• Number of cases: 1760

• No. of variables per record: 13

• Type of File: text/tab-separated-values

UNF:6:DbQMfdHQ6d2wQoRjHRojww==

• Number of cases: 42

• No. of variables per record: 18

• Type of File: text/tab-separated-values

UNF:6:UeNCoUbgHSWag6HgnWFfBQ==

• Number of cases: 42

• No. of variables per record: 17

• Type of File: text/tab-separated-values

UNF:6:F8vQ2O4KpvyFgGYd2++pAg==

• Number of cases: 57

• No. of variables per record: 12

• Type of File: text/tab-separated-values

UNF:6:pdujlv6xrYqKiAoOJhyWRw==

• NLC - NLC
• 24h - 24h
• C - C
• 7days - 7days
• E - E
• 15days - 15days
• G - G
• 21days - 21days
• I - I
• 30days - 30days
• K - K
• ResultsofDSCanalysisperformed24hafterpreparationofthesamples. - ResultsofDSCanalysisperformed24hafterpreparationofthesamples.
• B - B
• C - C
• D - D
• E - E
• F - F
• G - G
• H - H
• I - I
• J - J
• K - K
• L - L
• M - M
• N - N
• A - A
• Reflectance - Reflectance
• C - C
• D - D
• E - E
• F - F
• G - G
• H - H
• I - I
• J - J
• K - K
• L - L
• M - M
• A - A
• Abs - Abs
• 690nm - 690nm
• D - D
• E - E
• F - F
• G - G
• H - H
• I - I
• J - J
• Abs - Abs
• 690nm - 690nm
• M - M
• N - N
• O - O
• P - P
• Q - Q
• R - R
• A - A
• NE-IL1%unloaded - NE-IL1%unloaded
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• NE-IL1%+CBD - NE-IL1%+CBD
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• NLC-IL1%iunloaded - NLC-IL1%iunloaded
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• NLC-IL1%+CBD - NLC-IL1%+CBD
• PS(nm) - PS(nm)
• PDI - PDI
• Potencialzeta(mV) - Potencialzeta(mV)
• CBDconcentrationcalculatedwiththecalibrationcurveobtainedat08.08.2023(y=43625x+28827) - CBDconcentrationcalculatedwiththecalibrationcurveobtainedat08.08.2023(y=43625x+28827)
• B - B
• C - C
• D - D
• E - E
• F - F
• G - G
• H - H
• I - I
• J - J
• K - K
• L - L

f5313 Location:

Variable Format: character

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f5313 Location:

Variable Format: character

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f5313 Location:

Variable Format: character

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f5313 Location:

Variable Format: character

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f5313 Location:

Variable Format: character

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f5313 Location:

Variable Format: character

Notes: UNF:6:Gs4GP+g+0U1IbjL+7G3V2g==

f5313 Location:

Variable Format: character

Notes: UNF:6:+G5yLwIv5Y44BmnWq9kNcw==

f5313 Location:

Variable Format: character

Notes: UNF:6:VnwrBUrAmhMPJmfI1wU54Q==

f5313 Location:

Variable Format: character

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f5313 Location:

Variable Format: character

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f5313 Location:

Variable Format: character

Notes: UNF:6:0h8ir7qmk7gdyy4VHx5m7A==

f5312 Location:

Variable Format: character

Notes: UNF:6:P8bBtke5WpgGYA4fC/aZbQ==

f5312 Location:

Variable Format: character

Notes: UNF:6:+UNEUH3O6eLVgYEg/0XJ3Q==

f5312 Location:

Variable Format: character

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f5312 Location:

Variable Format: character

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f5312 Location:

Variable Format: character

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f5312 Location:

Variable Format: character

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f5312 Location:

Variable Format: character

Notes: UNF:6:49VF7nB9pRcYV0pLS7q3ZA==

f5312 Location:

Variable Format: character

Notes: UNF:6:cPQPlkmKzT/NY3wAPxzspA==

f5312 Location:

Variable Format: character

Notes: UNF:6:BpDuljC9lpod66r2ilZf7Q==

f5312 Location:

Variable Format: character

Notes: UNF:6:R7inMqdyeu+I5mKpVmkn1g==

f5312 Location:

Variable Format: character

Notes: UNF:6:7DC8RCnDdZXuEob2BMtdxg==

f5312 Location:

Variable Format: character

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f5312 Location:

Variable Format: character

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f5312 Location:

Variable Format: character

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f5311 Location:

Variable Format: character

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f5311 Location:

Variable Format: character

Notes: UNF:6:CODzbaoldZIT3AN5BcHhvA==

f5311 Location:

Summary Statistics: StDev 0.17211191679559693; Valid 1759.0; Max. 0.9573; Min. 0.42325; Mean 0.7580591984081865

Variable Format: numeric

Notes: UNF:6:PBR2RgC5mIBBTnjdvOa7RA==

f5311 Location:

Summary Statistics: Valid 1759.0; StDev 0.1770066580566327; Max. 0.96517; Mean 0.7645437976122796; Min. 0.41478;

Variable Format: numeric

Notes: UNF:6:OwY7NxL8Bhn2N2m4ouqowA==

f5311 Location:

Variable Format: character

Notes: UNF:6:9dJuHCuFvhJ4i7zHMet5rg==

f5311 Location:

Summary Statistics: Max. 0.95765; Valid 1759.0; Mean 0.7549927629334849; Min. 0.43147; StDev 0.16803963706353275;

Variable Format: numeric

Notes: UNF:6:4BaFS6OMW4anDOjOKEzDwQ==

f5311 Location:

Summary Statistics: Max. 0.85948; Min. 0.49538; Mean 0.7185676122797043; StDev 0.0875977986155012; Valid 1759.0

Variable Format: numeric

Notes: UNF:6:SbcaZNedk8Tv4VroNpvafg==

f5311 Location:

Variable Format: character

Notes: UNF:6:iTRU3omnVjrikpGkoctSlA==

f5311 Location:

Summary Statistics: StDev 0.160753486568283; Min. 0.43226; Valid 1759.0; Mean 0.7359041500852758; Max. 0.94197

Variable Format: numeric

Notes: UNF:6:9O/MRgs2P+eP4ONi7/ZyGg==

f5311 Location:

Summary Statistics: Max. 0.89162; Mean 0.7270136327458783; Valid 1759.0; StDev 0.11797863586965579; Min. 0.50275;

Variable Format: numeric

Notes: UNF:6:bgRiydZIdM0c19uNurq6BA==

f5311 Location:

Variable Format: character

Notes: UNF:6:e8XfZr/FsmFLAF7A1ePboQ==

f5311 Location:

Summary Statistics: Min. 0.44709; StDev 0.14463007035673836; Valid 1759.0; Max. 0.91247; Mean 0.7171516770892552

Variable Format: numeric

Notes: UNF:6:2TYUMUnU4Y6fToFNvut2Ew==

f5311 Location:

Summary Statistics: StDev 0.14896141839649502; Max. 0.92242; Min. 0.44375; Valid 1759.0; Mean 0.7212875781694145

Variable Format: numeric

Notes: UNF:6:uNu8hCIR97wUut7b32qKZw==

f5318 Location:

Summary Statistics: Mean NaN; Max. NaN; Min. NaN; Valid 0.0; StDev NaN;

Variable Format: numeric

Notes: UNF:6:68R9FoPx6LbVBr9D8H+T5g==

f5318 Location:

Variable Format: character

Notes: UNF:6:w59M2ewKEf4evlpkgdey0g==

f5318 Location:

Variable Format: character

Notes: UNF:6:rNKx9+5wQQTa4l8+5nhfrQ==

f5318 Location:

Variable Format: character

Notes: UNF:6:TkgZiSgQA0LHsRXLlUqtZg==

f5318 Location:

Variable Format: character

Notes: UNF:6:qJK7zfCBbarJ2H405P2UHg==

f5318 Location:

Summary Statistics: Mean 2.6681; Valid 30.0; Min. 0.045; StDev 6.163885062087116; Max. 25.0

Variable Format: numeric

Notes: UNF:6:DvPJg5piAjk4M0TsLHHrbQ==

f5318 Location:

Summary Statistics: StDev 12.433410821736286; Mean 4.5406; Min. 0.1; Max. 50.0; Valid 30.0

Variable Format: numeric

Notes: UNF:6:Xp7fNx9o5lCrMfpxAoD/4w==

f5318 Location:

Summary Statistics: StDev 25.10816978963336; Valid 30.0; Max. 100.0; Mean 8.088566666666667; Min. 0.039;

Variable Format: numeric

Notes: UNF:6:7XOJgRvNlS9EClKWZOf+PA==

f5318 Location:

Summary Statistics: Min. 0.046; Mean 19.008366666666667; Max. 250.0; StDev 63.09392185354244; Valid 30.0

Variable Format: numeric

Notes: UNF:6:K/7415XFbtCL4vAumiU0rQ==

f5318 Location:

Summary Statistics: Mean NaN; Min. NaN; Valid 0.0; Max. NaN; StDev NaN

Variable Format: numeric

Notes: UNF:6:68R9FoPx6LbVBr9D8H+T5g==

f5318 Location:

Variable Format: character

Notes: UNF:6:w59M2ewKEf4evlpkgdey0g==

f5318 Location:

Variable Format: character

Notes: UNF:6:rNKx9+5wQQTa4l8+5nhfrQ==

f5318 Location:

Variable Format: character

Notes: UNF:6:TkgZiSgQA0LHsRXLlUqtZg==

f5318 Location:

Variable Format: character

Notes: UNF:6:wf5YMQZBKwdjAXKarykt8A==

f5318 Location:

Summary Statistics: Max. 25.0; Mean 2.9444333333333335; Min. 0.132; StDev 6.091845763456846; Valid 30.0;

Variable Format: numeric

Notes: UNF:6:FMPCNJVPgepgGCDVPxY4lg==

f5318 Location:

Summary Statistics: Valid 30.0; StDev 12.360486587202537; Min. 0.125; Mean 4.9355; Max. 50.0

Variable Format: numeric

Notes: UNF:6:ZB3SxzyygkLXlAPq7NV1sg==

f5318 Location:

Summary Statistics: Mean 8.910366666666667; StDev 24.96896771578581; Min. 0.078; Valid 30.0; Max. 100.0;

Variable Format: numeric

Notes: UNF:6:0aiuICdgfEuQNKhve7UWhg==

f5318 Location:

Summary Statistics: Mean 20.765066666666666; StDev 62.865550820194336; Max. 250.0; Valid 30.0; Min. 0.049;

Variable Format: numeric

Notes: UNF:6:7x7zF2jhD0p7kI5n7Kkv/w==

f5314 Location:

Summary Statistics: Max. NaN; Mean NaN; Min. NaN; StDev NaN; Valid 0.0

Variable Format: numeric

Notes: UNF:6:68R9FoPx6LbVBr9D8H+T5g==

f5314 Location:

Variable Format: character

Notes: UNF:6:WQgF6YRLHXXLtDwMfaeFIg==

f5314 Location:

Summary Statistics: StDev 1682.6255587386743; Mean 1435.1222222222225; Valid 36.0; Min. 190.1; Max. 5750.0

Variable Format: numeric

Notes: UNF:6:0p54VII2gvtFrTFhfHrZAg==

f5314 Location:

Summary Statistics: Valid 36.0; StDev 0.27589316283950804; Mean 0.6103611111111111; Max. 1.0; Min. 0.247;

Variable Format: numeric

Notes: UNF:6:Zs5H/ayVqlnCmxoEriG5vg==

f5314 Location:

Summary Statistics: Max. 1.48; Valid 34.0; Min. -59.1; Mean -18.303952941176473; StDev 22.053452652441432;

Variable Format: numeric

Notes: UNF:6:uN3PM2ZXPe3KtLuGB79D2A==

f5314 Location:

Variable Format: character

Notes: UNF:6:nNLKn6EWoE1JHHBt1lWRTw==

f5314 Location:

Summary Statistics: StDev 6770.568566456616; Min. 159.1; Max. 28200.0; Mean 3474.4512820512828; Valid 39.0

Variable Format: numeric

Notes: UNF:6:YWo6fwSusa54gh3eTAqspw==

f5314 Location:

Summary Statistics: Max. 1.0; Min. 0.16; Valid 39.0; StDev 0.32742447491693233; Mean 0.6327179487179487;

Variable Format: numeric

Notes: UNF:6:/HY1ZCXJQgMBWI5Dna/9Ug==

f5314 Location:

Summary Statistics: StDev 19.559332641009853; Valid 39.0; Min. -46.8; Mean -25.744179487179483; Max. 4.19;

Variable Format: numeric

Notes: UNF:6:zChRE3ORfYm/y9/GH8bYEA==

f5314 Location:

Variable Format: character

Notes: UNF:6:F3xuBztKla2w1yaERWewow==

f5314 Location:

Summary Statistics: Min. 288.8; Max. 3014.0; Valid 35.0; Mean 711.9028571428572; StDev 605.1260080180259;

Variable Format: numeric

Notes: UNF:6:wgUnMLfawSgUIUssIKmypw==

f5314 Location:

Summary Statistics: StDev 0.2007631550968565; Min. 0.363; Max. 1.0; Mean 0.5666111111111112; Valid 36.0

Variable Format: numeric

Notes: UNF:6:buHbf0EOCh641FmPLSBwxw==

f5314 Location:

Summary Statistics: Max. 0.554; Mean -28.569684210526315; Min. -58.7; Valid 38.0; StDev 20.148677219146805;

Variable Format: numeric

Notes: UNF:6:V/C+FnvhtcX5q8vEwmnJsw==

f5314 Location:

Variable Format: character

Notes: UNF:6:9i6lKGzGwn9X8rUSZHDo7g==

f5314 Location:

Summary Statistics: StDev 9273.769394865436; Max. 42160.0; Valid 36.0; Min. 254.4; Mean 3569.033333333333;

Variable Format: numeric

Notes: UNF:6:G7T8lvo6MNLo78UzfBdMnA==

f5314 Location:

Summary Statistics: Min. 0.235; Max. 1.0; StDev 0.21952569904155309; Mean 0.5651944444444444; Valid 36.0;

Variable Format: numeric

Notes: UNF:6:xj32y74tLF1GlHjoIarYeg==

f5314 Location:

Summary Statistics: Valid 36.0; Mean -26.05638888888889; Min. -47.0; StDev 17.41977433883324; Max. 5.52

Variable Format: numeric

Notes: UNF:6:dAWjJLLxpOETISsrNtkZdA==

f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

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f5316 Location:

Variable Format: character

Notes: UNF:6:Lu+f+FFYZJh7kqQsi7PbrQ==

f5316 Location:

Variable Format: character

Notes: UNF:6:io9oZy/ozt+aEWG6eKRppA==

Label:

00_ReadMe.txt

text/plain

Label:

CBDHIGHBIO-101062938_Protocol 5 - NLCs-IL_v1.0.pdf

application/pdf

Label:

CBDHIGHBIO_101062938_Protocol 5_XRD.xlsx

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Label:

CBDHIGHBIO-101062938_Protocol 7 - Digestion_v1.0.pdf

application/pdf

Label:

Protocol 5_NE-IL e NLC-IL.mpx

application/octet-stream

Label:

Protocol 6_Cell viability.mpx

application/octet-stream

Label:

Protocol 7_Digestion.mpx

application/octet-stream