|
View: |
Part 1: Document Description
|
|
Citation |
|
|---|---|
|
Title: |
Data from the manuscript [A role of supraspinal galanin in behavioural hyperalgesia in the rat] |
|
Identification Number: |
doi:10.34622/datarepositorium/LOIUZR |
|
Distributor: |
Repositório de Dados da Universidade do Minho |
|
Date of Distribution: |
2022-12-22 |
|
Version: |
1 |
|
Bibliographic Citation: |
Amorim, Diana; David-Pereira, Ana; Marques, Patrícia; Puga, Sónia Andreia Silva; Rebelo, Patrícia; Costa, Patrício Soares; Pertovaara, Antti; Almeida, Armando; Pinto-Ribeiro, Filipa, 2022, "Data from the manuscript [A role of supraspinal galanin in behavioural hyperalgesia in the rat]", https://doi.org/10.34622/datarepositorium/LOIUZR, Repositório de Dados da Universidade do Minho, V1, UNF:6:0E6YdJOV/RocJMTXsGqMqg== [fileUNF] |
|
Citation |
|
|
Title: |
Data from the manuscript [A role of supraspinal galanin in behavioural hyperalgesia in the rat] |
|
Identification Number: |
doi:10.34622/datarepositorium/LOIUZR |
|
Authoring Entity: |
Amorim, Diana (Universidade do Minho) |
|
David-Pereira, Ana (Universidade do Minho) |
|
|
Marques, Patrícia (Universidade do Minho) |
|
|
Puga, Sónia Andreia Silva (Universidade do Minho) |
|
|
Rebelo, Patrícia (Universidade do Minho) |
|
|
Costa, Patrício Soares (Universidade do Minho) |
|
|
Pertovaara, Antti (Universidade do Minho) |
|
|
Almeida, Armando (Universidade do Minho) |
|
|
Pinto-Ribeiro, Filipa (Universidade do Minho) |
|
|
Date of Production: |
2014 |
|
Grant Number: |
PTDC/SAU-NEU/108557/2008 |
|
Grant Number: |
SFRH/BD/71219/2010 |
|
Grant Number: |
SFRH/BD/90374/2012 |
|
Distributor: |
Repositório de Dados da Universidade do Minho |
|
Access Authority: |
Vieira, Andre |
|
Depositor: |
Vieira, Andre |
|
Date of Deposit: |
2022-12-22 |
|
Study Scope |
|
|
Keywords: |
Medicine, Health and Life Sciences, experimental monoarthritis, pronociception, galanin receptor type-1, dorsomedial hypothalamic nucleus, rostral ventromedial medulla |
|
Abstract: |
In chronic pain disorders, galanin (GAL) is able to either facilitate or inhibit nociception in the spinal cord but the contribution of supraspinal galanin to pain signalling is mostly unknown. The dorsomedial nucleus of the hypothalamus (DMH) is rich in galanin receptors (GALR) and is involved in behavioural hyperalgesia. In this study, we evaluated the contribution of supraspinal GAL to behavioural hyperalgesia in experimental monoarthritis. In Wistar-Han males with a four week kaolin/carrageenan-induced monoarthritis (ARTH), paw-withdrawal latency (PWL) was assessed before and after DMH administration of exogenous GAL, a non-specific GALR antagonist (M40), a specific GALR1 agonist (M617) and a specific GALR2 antagonist (M871). Additionally, the analysis of c-Fos expression after GAL injection in the DMH was used to investigate the potential involvement of brainstem pain control centres. Finally, electrophysiological recordings were performed to evaluate whether pronociceptive On- or antinociceptive Off-like cells in the rostral ventromedial medulla (RVM) relay the effect of GAL. Exogenous GAL in the DMH decreased PWL in ARTH and SHAM animals, an effect that was mimicked by a GALR1 agonist (M617). In SHAM animals, an unselective GALR antagonist (M40) increased PWL, while a GALR2 antagonist (M871) decreased PWL. M40 or M871 failed to influence PWL in ARTH animals. Exogenous GAL increased c-Fos expression in the RVM and dorsal raphe nucleus (DRN), with effects being more prominent in SHAM than ARTH animals. Exogenous GAL failed to influence activity of RVM On- or Off-like cells of SHAM and ARTH animals. Overall, exogenous GAL in the DMH had a pronociceptive effect that is mediated by GALR1 in healthy and arthritic animals and is associated with alterations of c-Fos expression in RVM and DRN that are serotonergic brainstem nuclei known to be involved in the regulation of pain. |
|
Notes: |
This study was supported by grants from the Portuguese Science Foundation (FCT) Project nu PTDC/SAU-NEU/108557/2008, FEDER-COMPETE, by the Academy of Finland and the Sigrid Jusélius Foundation, Helsinki, Finland. DA was supported by FCT grant SFRH/BD/71219/2010 and ADP was supported by FCT grant SFRH/BD/90374/2012. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
|
Methodology and Processing |
|
|
Sources Statement |
|
|
Data Access |
|
|
Notes: |
CC0 Waiver |
|
Other Study Description Materials |
|
|
Related Publications |
|
|
Citation |
|
|
Identification Number: |
1822/32480 |
|
Bibliographic Citation: |
Amorim, D., David-Pereira, A., Marques, P., Puga, S., Rebelo, P., Costa, P., ... & Pinto-Ribeiro, F. (2014). A role of supraspinal galanin in behavioural hyperalgesia in the rat. PLoS One, 9(11), e113077. |
|
File Description--f2210 |
|
|
File: AmorimD_PLoSOne_Galanin_Data.tab |
|
|
|
|
Notes: |
UNF:6:0E6YdJOV/RocJMTXsGqMqg== |
|
List of Variables: |
|
|
Variables |
|
|
f2210 Location: |
Summary Statistics: Min. NaN; StDev NaN; Valid 0.0; Mean NaN; Max. NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:YYf/ejlPfEo0kEf1127v5A== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:Nhl17OmPsH0V+X1uNpZuRA== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:lJQCbfr5fQe3zAfEMHcd1Q== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:lP+czVyMRU0OS3IsRCLD+A== |
|
f2210 Location: |
Summary Statistics: StDev NaN; Max. NaN; Mean NaN; Valid 0.0; Min. NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Summary Statistics: Max. NaN; Min. NaN; Valid 0.0; Mean NaN; StDev NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:cvxQHBOSdcmqYsrBdO9wZQ== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:GE3oY1zrJewDTCtfFLfacg== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:gazuW1iVYQNKju5H3tF3xw== |
|
f2210 Location: |
Summary Statistics: Mean NaN; Max. NaN; StDev NaN; Valid 0.0; Min. NaN; Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:7f1o/WcqeC3aoxLYuMy6EQ== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:VSv5UD1l/6W6Drj+gBOYwA== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:3gHUX/DiILdSGcO32s5l9Q== |
|
f2210 Location: |
Summary Statistics: Min. NaN; Valid 0.0; Max. NaN; StDev NaN; Mean NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:fuDA0Apz9OYRtVpPKZB3pw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:+m7AvH/LuSNHSLDErFTbMA== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:dd42rtXvBk83WbwGnic/9g== |
|
f2210 Location: |
Summary Statistics: StDev NaN; Mean NaN; Min. NaN; Valid 0.0; Max. NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:TwnMUm1Mgf2k1JyvOh2xBg== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:cIlan3pbiCbQKjXS+DwTVQ== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:ipcvU8JDG8k7olV+I+2ZYA== |
|
f2210 Location: |
Summary Statistics: Mean NaN; Min. NaN; Max. NaN; Valid 0.0; StDev NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:EwFmwGllBPrhq/7rkf8+Cw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:JxjbNAkKWLs6npVHa5C6xA== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:WMkEKBVYbdJzuHxQMlA6lw== |
|
f2210 Location: |
Summary Statistics: Mean NaN; StDev NaN; Min. NaN; Valid 0.0; Max. NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:8A8KVeXFpOodM17EIdMnzA== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:YIFn7FRNf/RX6NuguTlM1w== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:5nUK1vDZt8t1zB45PmU6Kw== |
|
f2210 Location: |
Summary Statistics: Min. NaN; StDev NaN; Valid 0.0; Mean NaN; Max. NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:H4S9rDI5xl2Rx8sziT7k6w== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:ew2YDWXA/0Tz0GWLiML07g== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:3cGHokpjSfwVE5MCa/yPTA== |
|
f2210 Location: |
Summary Statistics: Max. NaN; Min. NaN; Mean NaN; StDev NaN; Valid 0.0 Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:HHFEdRAYfQQGYU2EkUc/PQ== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:LvOZLb4QRsWLyBhFBlzUiQ== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:wQyC93NIojhpHIwfAqDDZQ== |
|
f2210 Location: |
Summary Statistics: Max. NaN; StDev NaN; Mean NaN; Valid 0.0; Min. NaN Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:4PK4ZSgeRnrJa5O/9MJfQg== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:/RclVznEiLSJ62BXa3sJbg== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:dPu8IyuiZ4JOkDP14oc/TQ== |
|
f2210 Location: |
Summary Statistics: Min. NaN; Max. NaN; Mean NaN; StDev NaN; Valid 0.0 Variable Format: numeric Notes: UNF:6:VVJ0i1rrUA9Xs9H0pW5Olw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:sxegC+CPbm4Cgi7lz3QXuA== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:/DloycSBJEzG7L72N+ImEw== |
|
f2210 Location: |
Variable Format: character Notes: UNF:6:+7vJJ1YgyPjTWQ6NPFyYvQ== |